Open AccessDexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes
Author(s) -
Jonas Burén,
HX Liu,
Jørgen Jensen,
JW Eriksson
Publication year - 2002
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1460419
Subject(s) - medicine , endocrinology , insulin , glucose transporter , glut4 , insulin receptor , phosphatidylinositol , insulin resistance , glucose uptake , glucocorticoid , dexamethasone , basal (medicine) , insulin receptor substrate , biology , protein kinase b , irs1 , kinase , signal transduction , biochemistry
Glucocorticoid excess leads to insulin resistance. This study explores the effects of glucocorticoids on the glucose transport system and insulin signalling in rat adipocytes. The interaction between glucocorticoids and high levels of insulin and glucose is also addressed.
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