Open AccessEpitope mapping of cytochrome P450 cholesterol side-chain cleavage enzyme by sera from patients with autoimmune polyglandular syndrome type 1
Author(s) -
Ingrid Liiv,
Kaupo Teesalu,
Pärt Peterson,
Maria Grazia Clemente,
Jaakko Perheentupa,
Raivo Uibo
Publication year - 2002
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1460113
Subject(s) - epitope , autoantibody , cholesterol side chain cleavage enzyme , autoimmunity , antibody , autoimmune disease , polyclonal antibodies , microbiology and biotechnology , biology , chemistry , immunology , enzyme , cytochrome p450 , biochemistry
Autoimmune polyglandular syndrome type 1 (APS-1) is a disease associated with defects of the autoimmune regulator gene and is characterized by autoimmune lesions of several tissues, predominantly endocrine glands, with multiple autoantibodies. In this study we describe autoantigenic epitopes on cholesterol side-chain cleavage enzyme (P450scc) using sera from Finnish and Sardinian patients with APS-1, and analyze the epitope reactivities during disease follow-up.
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