Gonadal malignant germ cell tumors express immunoreactive inhibin/activin subunits | Zendy

L. Cobellis | Zendy; Palmina Cataldi | Zendy; Fernando M. Reis | Zendy; G. De Palo | Zendy; Francesco Raspagliesi | Zendy; S. Pilotti | Zendy; Felice Arcuri | Zendy; Felice Petraglia | Zendy

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Gonadal malignant germ cell tumors express immunoreactive inhibin/activin subunits

Author(s) -

L. Cobellis,

Palmina Cataldi,

Fernando M. Reis,

G. De Palo,

Francesco Raspagliesi,

S. Pilotti,

Felice Arcuri,

Felice Petraglia

Publication year - 2001

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1450779

Subject(s) - endocrinology , medicine , germ cell tumors , activin type 2 receptors , biology , tgf beta signaling pathway , transforming growth factor , chemotherapy

Inhibin and activin are proteins produced by ovarian granulosa cells and testicular Sertoli cells and are members of the transforming growth factor-beta superfamily. Since increased circulating levels of immunoreactive inhibin were detected in women with malignant ovarian tumors, they were proposed as tumor markers for ovarian carcinoma. Immunohistochemical studies later confirmed the presence of inhibin and activin subunits in granulosa cell tumors and epithelial ovarian cancer, as well as in Sertoli and Leydig cell testicular cancer. However, there is discrepant information on the detection of inhibin and activin in malignant germ cell tumors (MGCT). The aim of the present study was to evaluate the immunohistochemical expression of the inhibin/activin alpha, betaA and betaB subunits in ovarian and testicular MGCT specimens using polyclonal antisera.

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