Open AccessLovastatin-induced apoptosis in thyroid cells: involvement of cytochrome c and lamin B
Author(s) -
Tiziana Di Matola,
F. D’Ascoli,
Cristina Luongo,
Maurizio Bifulco,
Giacomo Rossi,
Gianfranco Fenzi,
Mario Vitale
Publication year - 2001
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1450645
Subject(s) - lamin , apoptosis , lovastatin , western blot , microbiology and biotechnology , cytochrome c , biology , biochemistry , cholesterol , gene , nucleus
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, lovastatin, induces apoptosis in the thyroid cell line TAD-2 and in proliferating normal human thyroid cells in culture, through a p53-independent mechanism involving caspase-3-like proteases. The combination of lovastatin with other anti-neoplastic drugs potentiates chemotherapy of tumors. This drug has been suggested for the chemotherapy of tumors and is potentially useful in the treatment of thyroid proliferative diseases. Based on this premise, we analyzed in more detail the role of some molecular effectors and the role of the caspase family proteases in the lovastatin-induced apoptotic pathway in TAD-2 cells.
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