Open AccessRET protein expression has no prognostic impact on the long-term outcome of papillary thyroid carcinoma
Author(s) -
Fulvio Basolo,
Eleonora Molinaro,
Laura Agate,
Aldo Pinchera,
Le Pollina,
Gennaro Chiappetta,
C Monaco,
Massimo Santoro,
Alfredo Fusco,
P. Miccoli,
Rossella Elisei,
Marco Capezzone,
Furio Pacini
Publication year - 2001
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1450599
Subject(s) - medicine , thyroid carcinoma , immunohistochemistry , thyroid cancer , thyroid , tyrosine kinase , carcinoma , papillary thyroid cancer , cancer , oncology , endocrinology , pathology , cancer research , receptor
RET proto-oncogene rearrangements (RET/PTC) are causative events in the pathogenesis of a subset of papillary thyroid cancer (PTC). The prevalence of RET/PTC varies in different countries and according to specific clinical features: it is higher after radiation exposure and it is claimed to be higher in young patients. Conflicting results are reported regarding the prognostic role of RET/PTC activation.
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