Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression during human gestation | Zendy

Ellen Schoof | Zendy; M. Girstl | Zendy; W. Frobenius | Zendy; Michael Kirschbaum | Zendy; Reinald Repp | Zendy; Ina Knerr | Zendy; Wolfgang Rascher | Zendy; Jörg Dötsch | Zendy

Open Access

Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression during human gestation

Author(s) -

Ellen Schoof,

M. Girstl,

W. Frobenius,

Michael Kirschbaum,

Reinald Repp,

Ina Knerr,

Wolfgang Rascher,

Jörg Dötsch

Publication year - 2001

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1450187

Subject(s) - medicine , endocrinology , placenta , fetus , gestation , dehydrogenase , biology , gene expression , cortisone , glucocorticoid , trophoblast , hydroxysteroid , pregnancy , decidua , 11β hydroxysteroid dehydrogenase type 1 , transplacental , enzyme , gene , biochemistry , genetics

During human pregnancy, 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) plays an important role in protecting the fetus from high maternal glucocorticoid concentrations by converting cortisol to inactive cortisone. Furthermore, 11beta-HSD2 is indirectly involved in the regulation of the prostaglandin inactivating enzyme 15-hydroxyprostaglandin dehydrogenase (PGDH), because cortisol reduces the gene expression and enzyme activity of PGDH in human placental cells.

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