Open AccessActions of gonadotropin-releasing hormone antagonists on steroidogenesis in human granulosa lutein cells
Author(s) -
Johannes M. Weiss,
Kerstin M. Oltmanns,
E.M. Gürke,
Stephan Polack,
F Eick,
R. Felberbaum,
K. Diedrich,
Olaf Ortmann
Publication year - 2001
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1440677
Subject(s) - triptorelin , medicine , endocrinology , human chorionic gonadotropin , gonadotropin , ovary , ovarian hyperstimulation syndrome , hormone , gonadotropin releasing hormone , in vivo , biology , in vitro fertilisation , luteinizing hormone , embryo , microbiology and biotechnology
GnRH antagonists have recently been introduced for the prevention of premature LH surges during controlled ovarian hyperstimulation (COH). We have here investigated whether the GnRH antagonists cetrorelix and ganirelix exert effects on ovarian steroidogenesis. Since there is some controversy about the action of GnRH agonists in the human ovary we also tested the effect of triptorelin on steroid production in cultured human granulosa lutein cells.
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