The decrease of IGF-I, IGF-binding protein-3 and bone alkaline phosphatase isoforms during gluten challenge correlates with small intestinal inflammation in children with coeliac disease | Zendy

UH Jansson | Zendy; B. Kristiansson | Zendy; Per Magnusson | Zendy; Laşse Larsson | Zendy; Kerstin AlbertssonWikland | Zendy; Ragnar Bjarnason | Zendy

Open Access

The decrease of IGF-I, IGF-binding protein-3 and bone alkaline phosphatase isoforms during gluten challenge correlates with small intestinal inflammation in children with coeliac disease

Author(s) -

UH Jansson,

B. Kristiansson,

Per Magnusson,

Laşse Larsson,

Kerstin AlbertssonWikland,

Ragnar Bjarnason

Publication year - 2001

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1440417

Subject(s) - medicine , endocrinology , alkaline phosphatase , gluten , coeliac disease , inflammation , enteropathy , bone remodeling , gene isoform , n terminal telopeptide , chemistry , biochemistry , osteocalcin , enzyme , disease , gene

In children with coeliac disease, the ingestion of gluten causes small intestinal inflammation and a clinical picture of malabsorption, weight reduction and short stature. Decreased alkaline phosphatase (ALP) during gluten challenge was found in a previous study. ALP is a marker of bone formation and ALP activities are correlated with growth velocity. The aim of this study was to characterise the previously observed decrease of total ALP by investigating three specific bone ALP isoforms (bone/intestinal, B1 and B2) and three specific liver ALP isoforms (L1, L2 and L3) and, moreover, to correlate these ALP isoforms with other growth factors and growth markers. In addition, we also studied the association with possible weight changes, small intestinal mucosa inflammation, sex, age and gluten dose during gluten challenge.

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