Endocrine factors related to changes in total peripheral vascular resistance after treatment of thyrotoxic and hypothyroid patients | Zendy

MJ Diekman | Zendy; MP Harms | Zendy; Erik Endert | Zendy; Wouter Wieling | Zendy; W. M. Wiersinga | Zendy

Open Access

Endocrine factors related to changes in total peripheral vascular resistance after treatment of thyrotoxic and hypothyroid patients

Author(s) -

MJ Diekman,

MP Harms,

Erik Endert,

Wouter Wieling,

W. M. Wiersinga

Publication year - 2001

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1440339

Subject(s) - euthyroid , medicine , endocrinology , hormone , vascular resistance , adrenomedullin , thyroid function , thyroid stimulating hormone , triiodothyronine , thyroid , blood pressure , receptor

Total peripheral vascular resistance (TPR) decreases in thyrotoxicosis and increases in hypothyroidism. Several mechanisms may be involved, including adaptation to changes in heat production and direct non-genomic effects of tri-iodothyronine (T3) on vascular smooth muscle cells. The aim of this study was to see if changes in TPR are related to changes in plasma concentrations of the endothelial hormones adrenomedullin and endothelin-1 as well as other hormones affecting vasculature.

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