Open AccessRegulation of the sodium iodide symporter by iodide in FRTL-5 cells
Author(s) -
PH Eng,
G R Cardona,
MC Previti,
WW Chin,
Lewis E. Braverman
Publication year - 2001
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1440139
Subject(s) - iodide , organification , sodium iodide symporter , chemistry , sodium iodide , symporter , iodine , endocrinology , medicine , biochemistry , biology , inorganic chemistry , gene , organic chemistry , transporter
The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect). We have recently reported that large doses of iodide given to rats chronically decrease the sodium/iodide symporter (NIS) mRNA and protein, suggesting that escape is due to a decrease in NIS and subsequent iodide transport. We have now studied the effect of excess iodide on NIS in FRTL-5 cells to further explore the mechanisms whereby excess iodide decreases NIS.
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