Genetic analysis of the INSL3 gene in patients with maldescent of the testis | Zendy

HN Lim | Zendy; E Raipert-de Meyts | Zendy; NE Skakkebæk | Zendy; IA Hughes | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genetic analysis of the INSL3 gene in patients with maldescent of the testis

Author(s) -

HN Lim,

E Raipert-de Meyts,

NE Skakkebæk,

IA Hughes

Publication year - 2001

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1440129

Subject(s) - biology , infertility , gene , testicle , endocrinology , medicine , mutation , testicular cancer , andrology , genetics , pregnancy , cancer

Testicular maldescent is important because it is a common congenital disorder that is associated with an increased risk of infertility and testicular cancer. Murine studies indicate that testicular maldescent can result from disruption of insulin-like factor 3 (INSL3) activity and that it may be more severe when there is concurrent undermasculinisation. Therefore, the INSL3 gene was screened for mutations and polymorphisms that may contribute to testicular maldescent in patients with undermasculinisation as well as those with isolated testicular maldescent.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research