Open AccessAssociation between the expression of E1A oncogene and increased sensitivity to growth inhibition induced by sustained levels of cAMP in rat thyroid cells
Author(s) -
Giovanni Villone,
Gabriella De Vita,
Paolo Chieffi,
Antonietta Picascia,
Rosita Stanzione,
Massimo Santoro,
Alfredo Fusco,
Donatella Tramontano
Publication year - 2000
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1420286
Subject(s) - cell culture , oncogene , cell growth , endocrinology , medicine , apoptosis , intracellular , thyroid , biology , cancer research , thyroid cancer , transfection , microbiology and biotechnology , cell cycle , genetics
The aim of this study was to investigate: (i) whether a persistent increase of cAMP interferes with the proliferation of transformed thyroid cells, and (ii) whether the degree of malignancy is correlated with the sensitivity to a transient and/or sustained increase in intracellular cAMP levels.
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