Open AccessAmino acid variants of the vitamin D-binding protein and risk of diabetes in white Americans of European origin
Author(s) -
Tomasz Klupa,
Maciej T. Małecki,
L Hanna,
J. Sieradzka,
J Frey,
J.H. Warram,
Jacek Sieradzki,
A S Krolewski
Publication year - 1999
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1410490
Subject(s) - haeiii , haplotype , genotype , exon , diabetes mellitus , biology , allele , type 2 diabetes , medicine , genetics , endocrinology , gene , white (mutation) , allele frequency , polymorphism (computer science) , vitamin d binding protein , vitamin , restriction fragment length polymorphism
Genetic variants of vitamin D-binding protein (DBP) have been reported to be associated, not only with diabetes, but also with prediabetic traits, in several populations. There are two known polymorphisms in exon 11 of the DBP gene that result in amino acid variants: at codons 416 GAT-->GAG (Asp-->Glu) and 420 ACG-->AAG (Thr-->Lys).
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