Increased levels of serum interleukin-12 in Graves' disease | Zendy

Masaaki Tamaru | Zendy; Bunzo Matsuura | Zendy; M Onji | Zendy

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Increased levels of serum interleukin-12 in Graves' disease

Author(s) -

Masaaki Tamaru,

Bunzo Matsuura,

M Onji

Publication year - 1999

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1410111

Subject(s) - medicine , endocrinology , propylthiouracil , graves' disease , thyroiditis , hormone , thyroid , free thyroxine , interleukin , triiodothyronine , stimulation , cytokine , thyroid function

We investigated serum total interleukin-12 (IL-12) levels in patients with Graves' disease and Hashimoto's thyroiditis. The serum IL-12 levels in Graves' disease were significantly increased in the hyperthyroid state, and were decreased during treatment with methimazole or propylthiouracil in accordance with the decline of free tri-iodothyronine (T(3)) levels, free thyroxine levels and thyroid-binding inhibiting immunoglobulin (TBII) levels. When T(3) was administered orally to normal subjects, serum IL-12 levels were slightly increased. These results suggest that IL-12 might be increased due to prolonged stimulation with thyroid hormone, and thyroid hormone by itself might be a self-perpetuating factor of Graves' disease via increased IL-12 production.

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