Open AccessProtective effect of dehydroepiandrosterone against lipid peroxidation in a human liver cell line
Author(s) -
Marco Gallo,
Manuela Aragno,
V Gatto,
Elena Tamagno,
Enrico Brignardello,
Roberta Manti,
Oliviero Danni,
G. Boccuzzi
Publication year - 1999
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1410035
Subject(s) - lipid peroxidation , tbars , dehydroepiandrosterone , endocrinology , medicine , chemistry , antioxidant , thiobarbituric acid , cumene hydroperoxide , oxidative stress , lactate dehydrogenase , glutathione , biochemistry , hormone , biology , androgen , enzyme , catalysis
Dehydroepiandrosterone (DHEA) is a widely studied steroid hormone with multi-functional properties. Reports suggest that some of the many activities of DHEA are due to its protective effect against lipid peroxidation. Nevertheless, the antioxidant properties of DHEA are still the subject of debate. The aim was to evaluate whether its two opposed effects on lipid peroxidation reported in the literature may be dependent on schedule and doses used.
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