Type 1 deiodinase is stimulated by iodothyronines and involved in thyroid hormone metabolism in human somatomammotroph GX cells | Zendy

A Baur | Zendy; Josef Köhrle | Zendy

Open Access

Type 1 deiodinase is stimulated by iodothyronines and involved in thyroid hormone metabolism in human somatomammotroph GX cells

Author(s) -

A Baur,

Josef Köhrle

Publication year - 1999

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1400367

Subject(s) - deiodinase , medicine , endocrinology , thyroid , hormone , chemistry , cell culture , iodothyronine deiodinase , anterior pituitary , enzyme , triiodothyronine , biology , biochemistry , genetics

Local 5'-deiOdination of l-thyroxine (T4) to the active thyroid hormone, 3,3',5-tri-iodothyronine (T3) via two deiodinase isoenzymes (D1 and D2) has an important role for various T3-dependent functions in the anterior pituitary. However, no evidence has been presented yet for thyroid hormone inactivation via the 5-deiodinase (D3) in anterior pituitary models.

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