Open AccessExpression of menin gene mRNA in pituitary tumours
Author(s) -
M A Satta,
Márta Korbonits,
Robert A. Jacobs,
DA Bolden-Dwinfour,
Gregory Kaltsas,
Valeria Vangeli,
Eric F. Adams,
R. Fahlbusch,
AB Grossman
Publication year - 1999
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1400358
Subject(s) - biology , carcinogenesis , exon , gene , gene expression , men1 , anterior pituitary , pituitary gland , endocrinology , multiple endocrine neoplasia , medicine , tumor suppressor gene , corticotropic cell , pituitary tumors , cancer research , hormone , genetics
Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant inherited disorder characterised by the combined occurrence of parathyroid, endocrine pancreas and anterior pituitary tumours. The gene responsible for MEN 1, the menin gene, a putative tumour-suppressor gene located on human chromosome 11q13, has been cloned. To investigate the role of the menin gene in sporadic anterior pituitary tumorigenesis, its mRNA was assessed in a group of pituitary tumours.
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