Natural killer cell activity in the peripheral blood of patients with Cushing's syndrome | Zendy

Masera Rg | Zendy; A. Staurenghi | Zendy; Sartori Ml | Zendy; Alberto Angeli | Zendy

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Natural killer cell activity in the peripheral blood of patients with Cushing's syndrome

Author(s) -

Masera Rg,

A. Staurenghi,

Sartori Ml,

Alberto Angeli

Publication year - 1999

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1400299

Subject(s) - medicine , peripheral blood , endocrinology , peripheral , cushing syndrome , cell , biology , genetics

Natural killer (NK) cells are CD3(-)CD16(+)CD56(+) bone-marrow-derived lymphocytes mediating first-line defence by direct cytotoxicity against various types of target cells without prior immunization. NK cell activity is positively regulated by immune interferon (IFN-gamma); among hormones, glucocorticoids are potent in vitro and in vivo inhibitors, whereas ACTH and beta-endorphin in many experimental circumstances enhance NK cytotoxicity.

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