Open AccessRANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case–cohort study, 1984–2002
Author(s) -
Christian Herder,
Thomas Illig,
Jens Baumert,
Martina MüllerNurasyid,
Norman Klopp,
Natalie Khuseyinova,
Christa Meisinger,
U Poschen,
Stéphan Martin,
Wolfgang Köenig,
Barbara Thorand
Publication year - 2008
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje-07-0686
Subject(s) - type 2 diabetes , ccl5 , medicine , haplotype , diabetes mellitus , endocrinology , genotype , chemokine , pathogenesis , adiponectin , population , immunology , biology , gene , insulin resistance , inflammation , genetics , t cell , immune system , environmental health , il 2 receptor
Regulated on activation, normal T-cell expressed and secreted (RANTES)/chemokine(C-C motif) ligand (CCL5) is expressed by adipocytes, and serum levels of RANTES are increased in obesity and type 2 diabetes. The aim of this study was to test the hypothesis that RANTES is involved in the pathogenesis of type 2 diabetes by analyzing the triangular association between CCL5 gene polymorphisms, systemic RANTES concentrations, and incident type 2 diabetes in a large prospective study.
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