Open AccessRole of the GH-IGF1 axis on the hypothalamus–pituitary–testicular axis function: lessons from Laron syndrome
Author(s) -
Rossella Cannarella,
Andrea Crafa,
Sandro La Vignera,
Rosita A. Condorelli,
Aldo E. Calogero
Publication year - 2021
Publication title -
endocrine connections
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 23
ISSN - 2049-3614
DOI - 10.1530/ec-21-0252
Subject(s) - medicine , endocrinology , testosterone (patch) , hypothalamic–pituitary–gonadal axis , fertility , delayed puberty , micropenis , infertility , hypothalamic disease , hormone , hypogonadotropic hypogonadism , luteinizing hormone , hypospadias , pregnancy , population , surgery , biology , environmental health , genetics
Animal studies suggest that insulin-like growth factor 1 (IGF1) may influence the function of the hypothalamus-pituitary-testicular axis, especially in childhood, but the evidence in humans is scanty. Laron syndrome, a human model of IGF1 deficiency, may help to solve this issue.