Open AccessKeep calm and transcribe on: chromatin changes with age, but transcription can learn to live with it
Author(s) -
Lynch Cian J,
Serrano Manuel
Publication year - 2022
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.15252/msb.202211276
Subject(s) - biology , chromatin , computational biology , data science , evolutionary biology , neuroscience , cognitive science , bioinformatics , genetics , gene , computer science , psychology
Assessing age‐related tissue dysfunction represents an emerging field and involves analyses that are far from trivial, often requiring the integration of several large‐scale (“omic”) techniques. In their recent work, Tessarz and colleagues (Bozukova et al , 2022) characterize changes in the transcriptional machinery during aging in mice and report some surprising findings.