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A Good Day for Helminths: how parasite‐derived GDH suppresses inflammatory responses
Author(s) -
Hodge Suzanne H,
McSorley Henry J
Publication year - 2022
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.202255054
Subject(s) - parasite hosting , helminths , biology , helminthiasis , microbiology and biotechnology , immunology , zoology , computer science , world wide web
Parasitic helminths are often associated with immunoregulation, which allows them to survive in their hosts in the face of type 2 immune responses. They achieve this feat through the secretion of multiple immunomodulatory factors. In this issue of EMBO Reports , Prodjinotho et al show that the parasitic cestode Taenia solium induces regulatory T‐cell responses in mice and humans through the release of the metabolic enzyme Glutamate dehydrogenase (GDH), which may be a conserved pathway of immunoregulation in many helminths (Prodjinotho et al , 2022).