Nephroprotective effect of vitamin E and bismuth combinationation in-Patients treated with cisplatin chemotherapy

Background and objectives: The objective of this study was to explore the optimal combination of agents with their doses used along with cisplatin for the protection of nephrototoxicity. Method: This experiment was carried out on patients suffering from different types of solid tumors divided into two groups: control group receiving cisplatin in a dose of 90 mg/ m² and the studied group receiving cisplatin in a dose of 90 mg/m² with bismuth subcitrate (200mg/ day) and vitamin E (400mg/day).Blood urea and serum creatinine were tested for the assessments of renal function. Results: control patients showed a sustain and significant elevation in blood urea and serum creatinine level in comparison with baseline along the entire period of the study, P<0.05. Meanwhile, the effect of cisplatin was shown to be significantly decreased in patients received bismuth-vitamin E therapy (P<0.05) along the entire period of the study. Conclusion: Bismuth and vitamin E in combination play a beneficial role for preventing cisplatin nephrototoxity. The potentiated actions for preventing cisplatin nephrototoxicity could be achieved via combined use of these agents.