English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background and objectives: The objective of this study was to explore the optimal combination of agents with their doses used along with cisplatin for the protection of hepatotoxicity. Methods: This experiment was carried out on a patients suffering from different solid types of tumor divided into two groups: cisplatin group receiving cisplatin in a dose of 90 mg/ m² body surface area(BSA) and the therapy group receiving cisplatin in a dose of 90 mg/m² BSA and bismuth subcitrate (200mg/day) with vitamin E (400mg/day). Ten healthy subjects were taken as a control group.Total serum bilirubin (TSB), serum glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) were tested for the assessments of liver function. Results: The level of TSB, GPT, GOT and ALP in healthy subjects did not changed significantly with respect to baseline value along the entire period of the study ; while cisplatin group showed a sustain and significant elevation in TSB, GPT, GOT and ALP level in comparison with baseline along the entire period of the study, P<0.05. Meanwhile, the hepatotoxic effect of cisplatin was shown to be slightly but however significantly decreased in patients received bismuth-vitamin E therapy (P<0.05) along the entire period of the study. Conclusion: Bismuth and vitamin E combination play a beneficial role for prevention of cisplatin hepatotoxicity. The potentiated actions for prevention of cisplatin hepatotoxicity could be achieved via combined use of these agents.

The preventive effect of bismuth and vitamin E combination on cisplatin hepatotoxicity in cancer patients