Effect of Platelet-rich Plasma on Implant Stability in the Mandible

Background and aims: Plasma rich in growth factors (PRGFs) has been recently proposed as an aid to enhance regeneration of osseous and epithelial tissues in oral surgery. The purpose of this study was to determine the effect of local application of Platelet Rich Plasma (PRP) on implant stability measured by periotest. Materials and Methods: A total of 24 implants were placed in mandible of 12 lower edentulous patients. In each patient, 2 implants were placed anterior to mental foramen in bilateral canine sites. One implant in each patient was dipped in autogenous PRP before insertion (test group), while the other implant was not embedded in PRP (control group). Repeated stability measurements were done by periotest on the day of surgery, 1, 2, 4 and 8 weeks after surgery. Results: In both groups minimum periotest values (highest stability) was observed in the day of surgery and 8 weeks after surgery. The maximum periotest values (lowest stability) were observed in 4th week after surgery. Considering implant stability, no statistically significant differences was observed between test and control groups at any time (P>0.05). In PRP group, the difference in implant stability between the day of surgery to 2nd and 4th weeks were statistically significant (p<0.05). Conclusion: Application of PRP on implant surface did not have an additional effect on implant stability in mandible.