The Photomodulation Activity of Metformin Against Oral Microbiome | Zendy

Shima Afrasiabi | Zendy; Maryam Pourhajibagher | Zendy; Abbas Bahador | Zendy

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The Photomodulation Activity of Metformin Against Oral Microbiome

Author(s) -

Shima Afrasiabi,

Maryam Pourhajibagher,

Abbas Bahador

Publication year - 2019

Publication title -

journal of lasers in medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.443

H-Index - 21

eISSN - 2228-6721

pISSN - 2008-9783

DOI - 10.15171/jlms.2019.39

Subject(s) - medicine , metformin , periodontitis , periodontium , microbiome , photodynamic therapy , intensive care medicine , chronic periodontitis , bioinformatics , dentistry , chemistry , organic chemistry , biology , insulin

Periodontitis is one of the most common inflammatory diseases of the periodontium, which results in the inflammatory destruction of supporting structures around teeth and is closely associated with the development of systemic disease. Due to a wide variety of antibiotic resistance periodontopathic bacteria, photodynamic therapy (PDT) is a non-invasive adjunctive therapeutic modality that is capable of destroying the whole range of microbes. Metformin (Metf) is an antidiabetic drug, and recent studies suggest that cancer patients who receive Metf and are exposed to radiotherapy and chemotherapy show better outcomes. Our surveys in this review introduce Metf as a potent stimulus in increasing the efficacy of PDT in the induction of destruction in microbial cells.

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