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Objective: Cholera is endemic in Iran and each year we are facing with some outbreaks throughout the country. The objective of this study was to analyze the isolated cholera strains at outbreak 2013 for studying the their similarity and compare their homology in order to find out the route of infection either emerge from abroad or reemerge from inside native strains. Methods: All diagnosed V. cholerae isolates were entered to the study after re-identification at referral laboratory of Health Ministry based on standard procedures. These specimens were examined for specific serogroups by O1 polyvalent and Ogawa/Inaba monospecific antisera and tested by MIC Test Strip Method against Ciprofloxacin, Nalidixic Acid, Cefixime, Ampicillin, Tetracycline, Trimethoprim-Sulfamethaxazone, and Erythromycin. Results: A total of 257 clinical Vibrio cholerae was isolated in an outbreak of Iran at 2013. The dominant causative type was Inaba. Vibrio cholerae was reported and isolated from 12 provinces, while 81.71% of cases from two southeast provinces. The outbreaks started from August and lasted in November. In Antibiotic susceptibility test isolates were 100% resistant to Nalidixic acid, Tetracycline and SXT while all were sensitive to Ciprofloxacin, Cefixime and Ampicillin. However, 23% of strains were sensitive to Erythromycin and all were isolated at the first two weeks of outbreak either from Iranian citizen or foreign travelers. Homology of isolates was investigated through genotyping by PFGE method and their clonality was compared with previous isolated Iranian native strain. Overall 92% of analyzed strains showed a homolog pattern. These strains were located in 8 clusters. Although isolated strains at 2011 had 80 % homology with recent isolates, located in complete distinct cluster than all strains isolated at 2013. PFGE analysis revealed no dissimilarity between those stains resistant and sensitive to Erythromycin. Conclusion: This study confirmed that isolated Inaba strains at 2013 had different clonality pattern in PFGE than previously identified, suggested have foreign route from the neighboring countries

Correlation of the Native Inaba Strain With the Dominant Isolated Strains Obtained From Outbreaks in 2013 in Iran