Comparative Study of Different Combinational Mucoadhesive Formulations of Sumatriptan-Metoclopramide | Zendy

Mitra Jelvehgari | Zendy; Hadi Valizadeh | Zendy; Sanam Ziapour | Zendy; Mahdieh Rahmani | Zendy; Seyed Hassan Montazam | Zendy; Saieede Soltani | Zendy

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Comparative Study of Different Combinational Mucoadhesive Formulations of Sumatriptan-Metoclopramide

Author(s) -

Mitra Jelvehgari,

Hadi Valizadeh,

Sanam Ziapour,

Mahdieh Rahmani,

Seyed Hassan Montazam,

Saieede Soltani

Publication year - 2016

Publication title -

advanced pharmaceutical bulletin

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.773

H-Index - 35

eISSN - 2251-7308

pISSN - 2228-5881

DOI - 10.15171/apb.2016.018

Subject(s) - bioavailability , differential scanning calorimetry , chemistry , particle size , buccal administration , mannitol , chromatography , hydroxypropyl cellulose , dosage form , polymer , materials science , nuclear chemistry , chemical engineering , pharmacology , organic chemistry , medicine , physics , engineering , thermodynamics

Sumatriptan succinate (Sum) is a Serotonin 5- HT1 receptor agonist, used in the treatment of migraine. It is absorbed rapidly but incompletely when taken orally and underwent first - pass metabolism, resulting in a low bioavailability of about 15%. The aim was to design mucoadhesive buccal discs and sublingual films of Sum and metoclopramide (Met) combined to improve their bioavailability.

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