Open AccessPulmonary Vascular Responses to Chronic Hypoxia Mediated by Hypoxia-inducible Factor 1
Author(s) -
Gregg L. Semenza
Publication year - 2005
Publication title -
proceedings of the american thoracic society
Language(s) - English
Resource type - Journals
eISSN - 1943-5665
pISSN - 1546-3222
DOI - 10.1513/pats.200404-029ms
Subject(s) - medicine , hypoxia (environmental) , cardiology , hypoxia inducible factors , pulmonary hypertension , oxygen , gene , biochemistry , chemistry , organic chemistry
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia. HIF-1 plays critical roles both during development and in response to physiologic and pathophysiologic stimuli in the adult. Here, the involvement of HIF-1 in lung pathophysiology will be discussed.
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