Acellular porcine and kangaroo aortic valve scaffolds show more intense immune-mediated calcification than cross-linked Toronto SPV(R) valves in the sheep model | Zendy

Guido Van Nooten | Zendy

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Acellular porcine and kangaroo aortic valve scaffolds show more intense immune-mediated calcification than cross-linked Toronto SPV(R) valves in the sheep model

Author(s) -

Guido Van Nooten

Publication year - 2006

Publication title -

interactive cardiovascular and thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.546

H-Index - 56

eISSN - 1569-9293

pISSN - 1569-9285

DOI - 10.1510/icvts.2006.136267

Subject(s) - decellularization , calcification , von kossa stain , calcinosis , glutaraldehyde , heart valve , medicine , matrix (chemical analysis) , extracellular matrix , aortic valve , calcium , anatomy , biomedical engineering , tissue engineering , pathology , surgery , chemistry , biology , microbiology and biotechnology , biochemistry , alkaline phosphatase , chromatography , enzyme

A major limitation of currently available bioprosthetic valves is their propensity to calcify. At present, one approach in tissue-engineering, uses decellularized, xenogenic scaffolds that are implanted, with the expectation of complete matrix repopulation in vivo. Whether or not such a decellularized matrix will be sufficiently endowed to prevent calcification is unknown.

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