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A major limitation of currently available bioprosthetic valves is their propensity to calcify. At present, one approach in tissue-engineering, uses decellularized, xenogenic scaffolds that are implanted, with the expectation of complete matrix repopulation in vivo. Whether or not such a decellularized matrix will be sufficiently endowed to prevent calcification is unknown.

interactive cardiovascular and thoracic surgery

Acellular porcine and kangaroo aortic valve scaffolds show more intense immune-mediated calcification than cross-linked Toronto SPV(R) valves in the sheep model