Induction of adipose tissue regeneration by chemically-modified hyaluronic acid | Zendy

Nicholas P. Rhodes | Zendy; Chiara Di Bartolo | Zendy; Davide Bellini | Zendy; John A. Hunt | Zendy

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Induction of adipose tissue regeneration by chemically-modified hyaluronic acid

Author(s) -

Nicholas P. Rhodes,

Chiara Di Bartolo,

Davide Bellini,

John A. Hunt

Publication year - 2008

Publication title -

international journal of nano and biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.112

H-Index - 11

eISSN - 1752-8941

pISSN - 1752-8933

DOI - 10.1504/ijnbm.2008.016874

Subject(s) - hyaluronic acid , adipose tissue , regeneration (biology) , capsule , histology , immunohistochemistry , chemistry , progenitor cell , tissue engineering , in vitro , biochemistry , biomedical engineering , microbiology and biotechnology , biology , anatomy , pathology , medicine , stem cell , immunology , botany

Hyaluronan was modified by amidation of the carboxyl groups with dodycyl amides to produce a viscous gel (HYADD3). Small aliquots were implanted intramuscularly in Wistar rats at a concentration of 30 mg/ml for up to 12 weeks. Standard histology and immunohistochemistry demonstrated low levels of inflammation at all time periods, absence of any fibrous capsule coupled with the presence of mature adipocytes within the degrading gel. It is concluded that the chemical architecture of HYADD3 gel causes the de novo regeneration of soft tissue by recruitment of appropriate progenitor cells.

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