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Cancer is an abnormal growth of cells caused by multiple changes in gene expression. Breast cancer is a cancer of the glandular breast tissue. The BRCA1 and BRCA2 genes were considered as greatly increasing occurrence of inherited breast cancer, however, it was found that the damaged ataxia telangiectasia mutated (ATM) genes were also equal culprits. The ATM gene (NC_000011.8) is very large and mutations occur throughout its amino acid coding portions. The present work discusses the use of bioinformatics tools in analysing the ATM gene's role in breast cancer.

Prediction of mutations in ATM gene responsible for breast cancer in women &ndash; a cancer-informatics approach

Prediction of mutations in ATM gene responsible for breast cancer in women – a cancer-informatics approach