CACNA1C polymorphism and brain cortical structure in bipolar disorder | Zendy

Erik Smedler | Zendy; Christoph Abé | Zendy; Erik Pålsson | Zendy; Martin Ingvar | Zendy; Mikael Landén | Zendy

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CACNA1C polymorphism and brain cortical structure in bipolar disorder

Author(s) -

Erik Smedler,

Christoph Abé,

Erik Pålsson,

Martin Ingvar,

Mikael Landén

Publication year - 2020

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.190029

Subject(s) - bipolar disorder , single nucleotide polymorphism , neuroscience , anterior cingulate cortex , medicine , biology , genetics , gene , genotype , cognition

The CACNA1C gene encodes the 1C subunit of L-type voltage-gated calcium channels and has been associated with several psychiatric syndromes — including bipolar disorder — in several genome-wide association studies. Experimental and clinical studies have reported changes with respect to behaviour and biomarkers in risk allele carriers, corroborating the essential role of the CACNA1C gene in neurons, during development and in the mature brain. However, the association of this gene with regional cortical thickness has not been evaluated in patients with bipolar disorder.

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