Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosa | Zendy

Ilka Boehm | Zendy; Esther Walton | Zendy; Nina Alexander | Zendy; Victoria-Luise Batury | Zendy; Maria Seidel | Zendy; Daniel Geisler | Zendy; Joseph A. King | Zendy; Kerstin Weidner | Zendy; Veit Roessner | Zendy; Stefan Ehrlich | Zendy

Open Access

Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosa

Author(s) -

Ilka Boehm,

Esther Walton,

Nina Alexander,

Victoria-Luise Batury,

Maria Seidel,

Daniel Geisler,

Joseph A. King,

Kerstin Weidner,

Veit Roessner,

Stefan Ehrlich

Publication year - 2020

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.190016

Subject(s) - dna methylation , epigenetics , serotonin transporter , methylation , psychology , psychopathology , medicine , endocrinology , genetics , psychiatry , biology , serotonin , gene , gene expression , receptor

Epigenetic variation in the serotonin transporter gene (SLC6A4) has been shown to modulate the functioning of brain circuitry associated with the salience network and may heighten the risk for mental illness. This study is, to our knowledge, the first to test this epigenome–brain–behaviour pathway in patients with anorexia nervosa.

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