Dorsolateral prefrontal γ-aminobutyric acid in patients with treatment-resistant depression after transcranial magnetic stimulation measured with magnetic resonance spectroscopy | Zendy

Jennifer G. Levitt | Zendy; Güldamla Kalender | Zendy; Joseph O’Neill | Zendy; Joel P. DiazFong | Zendy; Ian A. Cook | Zendy; Nathaniel D. Ginder | Zendy; David E. Krantz | Zendy; Michael Minzenberg | Zendy; Nikita Vince-Cruz | Zendy; Lydia D. Nguyen | Zendy; Jeffry R. Alger | Zendy; Andrew F. Leuchter | Zendy

Open Access

Dorsolateral prefrontal γ-aminobutyric acid in patients with treatment-resistant depression after transcranial magnetic stimulation measured with magnetic resonance spectroscopy

Author(s) -

Jennifer G. Levitt,

Güldamla Kalender,

Joseph O’Neill,

Joel P. DiazFong,

Ian A. Cook,

Nathaniel D. Ginder,

David E. Krantz,

Michael Minzenberg,

Nikita Vince-Cruz,

Lydia D. Nguyen,

Jeffry R. Alger,

Andrew F. Leuchter

Publication year - 2019

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.180230

Subject(s) - transcranial magnetic stimulation , dorsolateral prefrontal cortex , gabaergic , gamma aminobutyric acid , stimulation , psychology , medicine , agonist , gabaa receptor , prefrontal cortex , neuroscience , endocrinology , receptor , cognition

Treatment using rTMS was associated with increases in GABA levels at the stimulation site in the left DLPFC, and the degree of GABA change was related to clinical improvement. Participants receiving concomitant treatment with a GABA agonist were less likely to respond to rTMS. These findings were consistent with earlier studies showing theeffects of rTMS on GABA levels and support a GABAergic model of depression.

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