Large-scale evidence for an association between low-grade peripheral inflammation and brain structural alterations in major depression in the BiDirect study | Zendy

Nils Opel | Zendy; Micah Cearns | Zendy; Scott Clark | Zendy; Catherine Toben | Zendy; Dominik Grotegerd | Zendy; Walter Heindel | Zendy; Harald Kugel | Zendy; Anja Teuber | Zendy; Heike Minnerup | Zendy; Klaus Berger | Zendy; Udo Dannlowski | Zendy; Bernhard T. Baune | Zendy

Open Access

Large-scale evidence for an association between low-grade peripheral inflammation and brain structural alterations in major depression in the BiDirect study

Author(s) -

Nils Opel,

Micah Cearns,

Scott Clark,

Catherine Toben,

Dominik Grotegerd,

Walter Heindel,

Harald Kugel,

Anja Teuber,

Heike Minnerup,

Klaus Berger,

Udo Dannlowski,

Bernhard T. Baune

Publication year - 2019

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.180208

Subject(s) - grey matter , major depressive disorder , voxel based morphometry , insula , medicine , depression (economics) , body mass index , inflammation , brain size , psychology , gastroenterology , magnetic resonance imaging , neuroscience , amygdala , white matter , macroeconomics , economics , radiology

Preliminary research suggests that major depressive disorder (MDD) is associated with structural alterations in the brain; as well as with low-grade peripheral inflammation. However, even though a link between inflammatory processes and altered brain structural integrity has been purported by experimental research, well-powered studies to confirm this hypothesis in patients with MDD have been lacking. We aimed to investigate the potential association between structural brain alterations and low-grade inflammation as interrelated biological correlates of MDD.

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