Altered reward-related effective connectivity in obsessive-compulsive disorder: an fMRI study | Zendy

Ana Alves-Pinto | Zendy; Oana Georgiana Rus | Zendy; Tim Jonas Reeß | Zendy; Afra M. Wohlschläger | Zendy; Gerd Wagner | Zendy; Götz Berberich | Zendy; Kathrin Koch | Zendy

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Altered reward-related effective connectivity in obsessive-compulsive disorder: an fMRI study

Author(s) -

Ana Alves-Pinto,

Oana Georgiana Rus,

Tim Jonas Reeß,

Afra M. Wohlschläger,

Gerd Wagner,

Götz Berberich,

Kathrin Koch

Publication year - 2019

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.180195

Subject(s) - orbitofrontal cortex , psychology , context (archaeology) , default mode network , ventromedial prefrontal cortex , psychopathology , association (psychology) , amygdala , anxiety , neuroscience , prefrontal cortex , rumination , cognitive psychology , functional magnetic resonance imaging , clinical psychology , cognition , psychiatry , psychotherapist , paleontology , biology

Obsessive–compulsive disorder (OCD) is characterized by anxiety-provoking, obsessive thoughts. Patients usually react to these thoughts with repetitive behaviours that reduce anxiety and are perceived as rewarding. Hence, reward plays a major role in the psychopathology of OCD. Previous studies showed altered activation in frontostriatal networks, among others, in association with the processing of reward in patients with OCD. Potential alterations in connectivity within these networks have, however, barely been explored.

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