Open AccessGABA levels and TSPO expression in people at clinical high risk for psychosis and healthy volunteers: a PET-MRS study
Author(s) -
Tânia Maria Sarmento Silva,
Sina Hafizi,
Pablo Rusjan,
Sylvain Houle,
Alan A. Wilson,
Ivana Prce,
Napapon Sailasuta,
Romina Mizrahi
Publication year - 2019
Publication title -
journal of psychiatry and neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 99
eISSN - 1488-2434
pISSN - 1180-4882
DOI - 10.1503/jpn.170201
Subject(s) - translocator protein , gabaergic , psychosis , prefrontal cortex , medicine , positron emission tomography , psychology , schizophrenia (object oriented programming) , gamma aminobutyric acid , dorsolateral prefrontal cortex , endocrinology , neuroscience , pathophysiology , psychiatry , inflammation , receptor , neuroinflammation , cognition
γ-Aminobutyric acidergic (GABAergic) dysfunction and immune activation have been implicated in the pathophysiology of schizophrenia. Preclinical evidence suggests that inflammation-related abnormalities may contribute to GABAergic alterations in the brain, but this has never been investigated in vivo in humans. In this multimodal imaging study, we quantified cerebral GABA plus macromolecule (GABA+) levels in antipsychotic-naive people at clinical high risk for psychosis and in healthy volunteers. We investigated for the first time the association between GABA+ levels and expression of translocator protein 18 kDa (TSPO; a marker of microglial activation) using positron emission tomography (PET).
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