ERβ agonist alters RNA splicing factor expression and has a longer window of antidepressant effectiveness than estradiol after long-term ovariectomy | Zendy

Xu Hou | Zendy; Samuel O. Adeosun | Zendy; Xueying Zhao | Zendy; Rosanne Hill | Zendy; Baoying Zheng | Zendy; Reveena Reddy | Zendy; Xiao Su | Zendy; Jeffrey H. Meyer | Zendy; Thomas H. Mosley | Zendy; Jun Ming Wang | Zendy

Open Access

ERβ agonist alters RNA splicing factor expression and has a longer window of antidepressant effectiveness than estradiol after long-term ovariectomy

Author(s) -

Xu Hou,

Samuel O. Adeosun,

Xueying Zhao,

Rosanne Hill,

Baoying Zheng,

Reveena Reddy,

Xiao Su,

Jeffrey H. Meyer,

Thomas H. Mosley,

Jun Ming Wang

Publication year - 2018

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.170199

Subject(s) - tph2 , medicine , endocrinology , agonist , alternative splicing , biology , exon , serotonin , receptor , serotonergic , gene , biochemistry

These findings suggest that ERβ alternative splicing and altered responses in the regulatory system for serotonin may mediate the antidepressant efficacy of ET associated with the timing of therapy initiation. It is likely that ERβ-specific ligands would be effective estrogen-based antidepressants late after the onset of menopause.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research