Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder | Zendy

Fiona D. Zeeb | Zendy; Zhaoxia Li | Zendy; Daniel C. Fisher | Zendy; Martin Zack | Zendy; Paul Fletcher | Zendy

Open Access

Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder

Author(s) -

Fiona D. Zeeb,

Zhaoxia Li,

Daniel C. Fisher,

Martin Zack,

Paul Fletcher

Publication year - 2017

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.170003

Subject(s) - psychology , amphetamine , sensitization , iowa gambling task , saccharin , addiction , conditioned place preference , substance abuse , psychiatry , dopamine , developmental psychology , cognition , medicine , neuroscience

An animal model of gambling disorder, previously known as pathological gambling, could advance our understanding of the disorder and help with treatment development. We hypothesized that repeated exposure to uncertainty during gambling induces behavioural and dopamine (DA) sensitization - similar to chronic exposure to drugs of abuse. Uncertainty exposure (UE) may also increase risky decision-making in an animal model of gambling disorder.

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