Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder | Zendy

Miquel À. Fullana | Zendy; Xi Zhu | Zendy; Pino Alonso | Zendy; Narcı́s Cardoner | Zendy; Eva Real | Zendy; Clara LópezSolà | Zendy; Cinto Segalàs | Zendy; Marta Subirà | Zendy; Hanga Galfalvy | Zendy; José M. Menchón | Zendy; H. Blair Simpson | Zendy; Rachel Marsh | Zendy; Carles SorianoMas | Zendy

Open Access

Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder

Author(s) -

Miquel À. Fullana,

Xi Zhu,

Pino Alonso,

Narcı́s Cardoner,

Eva Real,

Clara LópezSolà,

Cinto Segalàs,

Marta Subirà,

Hanga Galfalvy,

José M. Menchón,

H. Blair Simpson,

Rachel Marsh,

Carles SorianoMas

Publication year - 2017

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.160215

Subject(s) - ventromedial prefrontal cortex , psychology , amygdala , cognition , anxiety , basolateral amygdala , prefrontal cortex , clinical psychology , cognitive behavioral therapy , psychiatry , medicine , neuroscience

Cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differences in basolateral amygdala-ventromedial prefrontal cortex (BLA-vmPFC) communication would predict CBT outcome in patients with OCD.

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