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Prefrontal brain responsiveness to negative stimuli
Author(s) -
Nils Opel,
Ronny Redlich,
Dominik Grotegerd,
Katharina Dohm,
Dario Zaremba,
Susanne Meinert,
Christian Bürger,
Leonie Plümpe,
Judith Alferink,
Walter Heindel,
Harald Kugel,
Peter Zwanzger,
Volker Arolt,
Udo Dannlowski
Publication year - 2017
Publication title -
journal of psychiatry and neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 99
eISSN - 1488-2434
pISSN - 1180-4882
DOI - 10.1503/jpn.160198
Subject(s) - major depressive disorder , dorsolateral prefrontal cortex , prefrontal cortex , orbitofrontal cortex , depression (economics) , psychology , family history , default mode network , medicine , psychiatry , clinical psychology , neuroscience , cognition , economics , macroeconomics
Identifying reliable trait markers of familial risk for major depressive disorder (MDD) is a challenge in translational psychiatric research. In individuals with acute MDD, dysfunctional connectivity patterns of prefrontal areas have been shown repeatedly. However, it has been unclear in which neuronal networks functional alterations in individuals at familial risk for MDD might be present and to what extent they resemble findings previously reported in those with acute MDD.

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