Accelerated aging of the putamen in patients with major depressive disorder | Zendy

Matthew D. Sacchet | Zendy; M. Catalina Camacho | Zendy; Emily E. Livermore | Zendy; Ewart A. C. Thomas | Zendy; Ian H. Gotlib | Zendy

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Accelerated aging of the putamen in patients with major depressive disorder

Author(s) -

Matthew D. Sacchet,

M. Catalina Camacho,

Emily E. Livermore,

Ewart A. C. Thomas,

Ian H. Gotlib

Publication year - 2017

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.160010

Subject(s) - putamen , major depressive disorder , psychology , anhedonia , medicine , basal ganglia , neuroscience , psychiatry , schizophrenia (object oriented programming) , central nervous system , mood

Growing evidence indicates that major depressive disorder (MDD) is characterized by accelerated biological aging, including greater age-related changes in physiological functioning. The disorder is also associated with abnormal neural reward circuitry, particularly in the basal ganglia (BG). Here we assessed age-related changes in BG volume in both patients with MDD and healthy control participants.

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