COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume | Zendy

Jasmeet P. Hayes | Zendy; Mark W. Logue | Zendy; Andrew J. Reagan | Zendy; David H. Salat | Zendy; Erika J. Wolf | Zendy; Naomi Sadeh | Zendy; Jeffrey M. Spielberg | Zendy; Emily Sperbeck | Zendy; Scott M. Hayes | Zendy; Regina E. McGlinchey | Zendy; William Milberg | Zendy; Mieke Verfaellie | Zendy; Annjanette Stone | Zendy; Steven A. Schichman | Zendy; Mark W. Miller | Zendy

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COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume

Author(s) -

Jasmeet P. Hayes,

Mark W. Logue,

Andrew J. Reagan,

David H. Salat,

Erika J. Wolf,

Naomi Sadeh,

Jeffrey M. Spielberg,

Emily Sperbeck,

Scott M. Hayes,

Regina E. McGlinchey,

William Milberg,

Mieke Verfaellie,

Annjanette Stone,

Steven A. Schichman,

Mark W. Miller

Publication year - 2017

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.150339

Subject(s) - hippocampal formation , neuroimaging , psychology , posttraumatic stress , medicine , hippocampus , clinical psychology , catechol o methyl transferase , psychiatry , oncology , genotype , neuroscience , genetics , gene , biology

Memory-based alterations are among the hallmark symptoms of posttraumatic stress disorder (PTSD) and may be associated with the integrity of the hippocampus. However, neuroimaging studies of hippocampal volume in individuals with PTSD have yielded inconsistent results, raising the possibility that various moderators, such as genetic factors, may influence this association. We examined whether the catechol-O-methyltransferase (COMT) Val158Met polymorphism, which has previously been shown to be associated with hippocampal volume in healthy individuals, moderates the association between PTSD and hippocampal volume.

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