Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: a neuroimaging genetics study | Zendy

Joseph J. Shenker | Zendy; Sarojini M. Sengupta | Zendy; Ridha Joober | Zendy; Ashok Malla | Zendy; M. Mallar Chakravarty | Zendy; Martín Lepage | Zendy

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Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: a neuroimaging genetics study

Author(s) -

Joseph J. Shenker,

Sarojini M. Sengupta,

Ridha Joober,

Ashok Malla,

M. Mallar Chakravarty,

Martín Lepage

Publication year - 2017

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.150332

Subject(s) - bipolar disorder , schizophrenia (object oriented programming) , genome wide association study , neuroimaging , medicine , psychology , psychiatry , genotype , genetics , single nucleotide polymorphism , gene , biology , cognition

Despite being diagnostically associated uniquely with schizophrenia, negative symptoms are also observed in bipolar disorder (BD). Genome-wide association studies (GWAS) have uncovered a number of shared risk genes between schizophrenia and BD. The objectives of this study were to examine whether previously identified risk genes for BD are associated with negative symptom severity within a first-episode schizophrenia (FES) cohort and to examine whether such genes influence brain morphology.

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