The effect of methylphenidate intake on brain structure in adults with ADHD in a placebo-controlled randomized trial | Zendy

Ludger Tebartz van Elst | Zendy; Simon Maier | Zendy; Stefan Klöppel | Zendy; Erika Graf | Zendy; Carola Killius | Zendy; Marthe Rump | Zendy; Esther Sobanski | Zendy; Dieter Ebert | Zendy; Thomas Berger | Zendy; Andreas Warnke | Zendy; Swantje Matthies | Zendy; Evgeniy Perlov | Zendy; Alexandra Philipsen | Zendy

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The effect of methylphenidate intake on brain structure in adults with ADHD in a placebo-controlled randomized trial

Author(s) -

Ludger Tebartz van Elst,

Simon Maier,

Stefan Klöppel,

Erika Graf,

Carola Killius,

Marthe Rump,

Esther Sobanski,

Dieter Ebert,

Thomas Berger,

Andreas Warnke,

Swantje Matthies,

Evgeniy Perlov,

Alexandra Philipsen

Publication year - 2016

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.150320

Subject(s) - methylphenidate , placebo , cohort , attention deficit hyperactivity disorder , psychology , grey matter , psychiatry , cohort study , pediatrics , anesthesia , medicine , magnetic resonance imaging , pathology , alternative medicine , white matter , radiology

Based on animal research several authors have warned that the application of methylphenidate, the first-line drug for the treatment of attention-deficit/hyperactivity disorder (ADHD), might have neurotoxic effects potentially harming the brain. We investigated whether methylphenidate application, over a 1-year period, results in cerebral volume decrease.

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