Elevated prefrontal cortex GABA in patients with major depressive disorder after TMS treatment measured with proton magnetic resonance spectroscopy | Zendy

Marc J. Dubin | Zendy; Xiangling Mao | Zendy; Samprit Banerjee | Zendy; Zachary T. Goodman | Zendy; Kyle Lapidus | Zendy; Guoxin Kang | Zendy; Conor Liston | Zendy; Dikoma C. Shungu | Zendy

Open Access

Elevated prefrontal cortex GABA in patients with major depressive disorder after TMS treatment measured with proton magnetic resonance spectroscopy

Author(s) -

Marc J. Dubin,

Xiangling Mao,

Samprit Banerjee,

Zachary T. Goodman,

Kyle Lapidus,

Guoxin Kang,

Conor Liston,

Dikoma C. Shungu

Publication year - 2016

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.150223

Subject(s) - transcranial magnetic stimulation , gabaergic , prefrontal cortex , dorsolateral prefrontal cortex , glutamate receptor , major depressive disorder , gamma aminobutyric acid , medicine , psychology , hamilton rating scale for depression , neuroscience , endocrinology , stimulation , inhibitory postsynaptic potential , receptor , cognition

GABAergic and glutamatergic neurotransmitter systems are central to the pathophysiology of depression and are potential targets of repetitive transcranial magnetic stimulation (rTMS). We assessed the effect of 10-Hz rTMS over the left dorsolateral prefrontal cortex (DLPFC) of patients with major depressive disorder on the levels of medial prefrontal cortex (MPFC) γ-aminobutyric acid (GABA) and the combined resonance of glutamate and glutamine (Glx) as assessed in vivo with proton magnetic resonance spectroscopy ((1)H MRS).

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