Global brain connectivity alterations in patients with schizophrenia and bipolar spectrum disorders | Zendy

Kristina C. Skåtun | Zendy; Tobias Kaufmann | Zendy; Siren Tønnesen | Zendy; Guido Biele | Zendy; Ingrid Melle | Zendy; Ingrid Agartz | Zendy; Dag Alnæs | Zendy; Ole A. Andreassen | Zendy; Lars T. Westlye | Zendy

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Global brain connectivity alterations in patients with schizophrenia and bipolar spectrum disorders

Author(s) -

Kristina C. Skåtun,

Tobias Kaufmann,

Siren Tønnesen,

Guido Biele,

Ingrid Melle,

Ingrid Agartz,

Dag Alnæs,

Ole A. Andreassen,

Lars T. Westlye

Publication year - 2016

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.150159

Subject(s) - schizophrenia spectrum , bipolar disorder , schizophrenia (object oriented programming) , neuroscience , functional connectivity , psychiatry , psychology , medicine , psychosis , cognition

The human brain is organized into functionally distinct modules of which interactions constitute the human functional connectome. Accumulating evidence has implicated perturbations in the patterns of brain connectivity across a range of neurologic and neuropsychiatric disorders, but little is known about diagnostic specificity. Schizophrenia and bipolar disorders are severe mental disorders with partly overlapping symptomatology. Neuroimaging has demonstrated brain network disintegration in the pathophysiologies; however, to which degree the 2 diagnoses present with overlapping abnormalities remains unclear.

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