MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression | Zendy

Armaz Aschrafi | Zendy; Jan Verheijen | Zendy; Peter Gordebeke | Zendy; Nikkie F. Olde Loohuis | Zendy; Kelly Willemijn Menting | Zendy; Amanda Jager | Zendy; Miklós Palkovits | Zendy; Bram Geenen | Zendy; Aron Kos | Zendy; Gerard J.M. Martens | Zendy; Jeffrey Glen | Zendy; Barry B. Kaplan | Zendy; Balázs Gaszner | Zendy; Tamás Kozicz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression

Author(s) -

Armaz Aschrafi,

Jan Verheijen,

Peter Gordebeke,

Nikkie F. Olde Loohuis,

Kelly Willemijn Menting,

Amanda Jager,

Miklós Palkovits,

Bram Geenen,

Aron Kos,

Gerard J.M. Martens,

Jeffrey Glen,

Barry B. Kaplan,

Balázs Gaszner,

Tamás Kozicz

Publication year - 2016

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.150154

Subject(s) - microrna , midbrain , endocrinology , medicine , downregulation and upregulation , urocortin , neuropeptide , biology , chemistry , neuroscience , receptor , gene , central nervous system , genetics

Altered levels of urocortin 1 (Ucn1) in the centrally projecting Edinger-Westphal nucleus (EWcp) of depressed suicide attempters or completers mediate the brain's response to stress, while the mechanism regulating Ucn1 expression is unknown. We tested the hypothesis that microRNAs (miRNAs), which are vital fine-tuners of gene expression during the brain's response to stress, have the capacity to modulate Ucn1 expression.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research