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Cortical thickness, volume and surface area in patients with bipolar disorder types I and II
Author(s) -
Christoph Abé,
Carl Johan Ekman,
Carl M. Sellgren,
Predrag Petrović,
Martin Ingvar,
Mikael Landén
Publication year - 2016
Publication title -
journal of psychiatry and neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 99
eISSN - 1488-2434
pISSN - 1180-4882
DOI - 10.1503/jpn.150093
Subject(s) - hypomania , brain size , bipolar disorder , medicine , mania , neuroscience , cognition , psychiatry , magnetic resonance imaging , psychology , radiology
Bipolar disorder (BD) is a common chronic psychiatric disorder mainly characterized by episodes of mania, hypomania and depression. The disorder is associated with cognitive impairments and structural brain abnormalities, such as lower cortical volumes in primarily frontal brain regions than healthy controls. Although bipolar disorder types I (BDI) and II (BDII) exhibit different symptoms and severity, previous studies have focused on BDI. Furthermore, the most frequently investigated measure in this population is cortical volume. The aim of our study was to investigate abnormalities in patients with BDI and BDII by simultaneously analyzing cortical volume, thickness and surface area, which yields more information about disease- and symptom-related neurobiology.

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